ACETYL l -ISOLEUCINE AND ACETYL l -LEUCINE AS EXTRACELLULAR PRODUCTS OF MYCOBACTERIUM RANAE

Acetyl-L-Carnitine Monograph

Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...

Biosynthesis of leupeptin. III. Isolation and properties of an enzyme synthesizing acetyl-L-leucine.

An enzyme which catalyzes acetylation of L-leucine with acetyl-CoA was partially purified from a cell extract of Streptomyces roseus MA839-A1, a leupeptin producer. The molecular weight of this enzyme is about 27,000 daltons. The enzyme has fairly broad specificity for acyl donors (I) and acceptors (II): as for I, propionyl-CoA was 1/10 as active as acetyl-CoA with L-leucine as the acceptor; as...

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy